Generic Name: Ondansetron BP 4 mg/5 ml
Therapeutic Class: Anti-emetics drugs
Indication: Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting. VomitOF (Ondansetron BP) is indicated for:
• Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy
• Prevention of nausea and vomiting associated with radiotherapy
• Prevention of postoperative nausea and vomiting
Dosage & Administration: Chemotherapy-induced Nausea and Vomiting:
Adults/ Geriatric/ Child of 12 years or over:
Highly emetogenic cancer chemotherapy: 30 ml (24 mg) VomitOF Oral Solution administered 30 minutes before the start of emetogenic chemotherapy.
Moderate emetogenic cancer chemotherapy: 10 ml (8 mg) VomitOF Oral Solution administered 30 minutes before the start of emetogenic chemotherapy.
A further 10 ml dose should be administered after 8 hours of the first dose. One 10 ml dose should be administered twice a day (every 12 hours) for 1-2 days after completion of chemotherapy.
Pediatric (4-11 years): 5 ml (4 mg) VomitOF Oral Solution should be taken 30 minutes before the start of chemotherapy. The other 2 doses should be taken 4 and 8 hours after the first dose. Then 5 ml oral solution should be administered 3 times a day (every 8 hours) for 1-2 days after completion of chemotherapy.
Radiotherapy induced Nausea and Vomiting:
Adults/ Geriatric/ Child of 12 years or over:
The recommended oral dosage is 10 ml (8 mg) VomitOF Oral Solution 3 times daily. For total body irradiation, 10 ml (8-mg) VomitOF Oral Solution should be administered 1 to 2 hours before each fraction of radiotherapy is administered each day.
For single high-dose fraction radiotherapy to the abdomen, one 10 ml VomitOF Oral Solution should be administered 1 to 2 hours before radiotherapy, with
subsequent doses every 8 hours after the first dose for 1 to 2 days after completion of radiotherapy.
For daily fractionated radiotherapy to the abdomen, 10 ml (8-mg) VomitOF Oral Solution should be administered 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for each day radiotherapy is given.
Postoperative Nausea and Vomiting:
Adults/ Geriatric/ Child of 12 years or over:
20 ml (16 mg) VomitOF Oral Solution 1 hour before induction of anesthesia.
Preparation: A bottle containing 50 ml syrup and a measuring cup.